The internet is buzzing with claims that tretinoin, a powerful prescription skincare ingredient, can boost hair growth. But is there real science behind this trend? Dermatologists say the story is more nuanced. While tretinoin has long been combined with minoxidil (the proven hair loss treatment) by some practitioners, solid evidence supporting its solo use for hair regrowth remains scarce.
The Basics of Tretinoin
Tretinoin is a retinoid, derived from vitamin A, and primarily used to treat acne, aging, and hyperpigmentation. It works by accelerating skin cell turnover, reducing inflammation, and unclogging pores. This multitasking ability has led some to believe it can also “prepare” the scalp for better absorption of minoxidil.
The Minoxidil Connection
The idea isn’t new. Dermatologists have been combining tretinoin with minoxidil for years, theorizing that tretinoin’s exfoliating effect could help minoxidil penetrate the scalp more effectively. Some older studies suggest that tretinoin can indeed increase minoxidil absorption, though the benefits are still under debate. One study found that using both together resulted in three times more minoxidil being absorbed compared to using minoxidil alone.
Limited Evidence, Mixed Results
Despite the theory, high-quality research on tretinoin for hair growth is lacking. Many studies are decades old and offer inconsistent results. Dermatologists generally don’t recommend it as a first-line treatment, emphasizing that the evidence simply isn’t compelling enough.
Recent studies are equally inconclusive. One 2025 trial with just 20 participants showed some improvement in hair count and density, but the small sample size and lack of comparison to minoxidil alone make it hard to draw firm conclusions. Other research even suggests that high concentrations of tretinoin could worsen hair loss over time.
Risks and Considerations
Using tretinoin on the scalp isn’t inherently dangerous, but it can cause irritation, dryness, and peeling. Combining it with minoxidil doubles the risk of these side effects. Given the limited evidence, dermatologists suggest that the potential payoff doesn’t justify the added discomfort.
What Works for Hair Loss?
The gold standard for hair loss remains minoxidil, particularly the 5% topical solution. While the exact mechanism isn’t fully understood, it prolongs hair growth and can reverse follicle miniaturization. Oral minoxidil, available by prescription, may be even more effective but carries a higher risk of side effects like weight gain and rapid heartbeat.
Other types of hair loss, such as those triggered by stress or autoimmune conditions, require different approaches. But for androgenetic alopecia (male and female pattern baldness), minoxidil is the most reliable option.
In conclusion: Tretinoin might have a minor supporting role in enhancing minoxidil absorption, but it’s not a miracle cure for hair loss. The evidence remains weak, and using it without guidance from a dermatologist could be counterproductive. If you’re serious about hair growth, stick with proven treatments like minoxidil and consult a professional for personalized advice.
